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KMID : 1188320170110030426
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Gut and Liver
2017 Volume.11 No. 3 p.426 ~ p.433
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Prevalence and Incidence of Depression during Interferon-Based Antiviral Therapy in Chronic Hepatitis C Patients in the Republic of Korea
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Baeg Joo-Yeong
Kim In-Hee
Seo Seung-Young
Kim Young-Seok
Jung Eun-Uk
Cho Jun-Hyeon
Chung Jung-Wha
Jang Eun-Sun
Kim Jin-Wook
Jeong Sook-Hyang
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Abstract
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Background/Aims: The association between depression and chronic hepatitis C virus (HCV) infection or pegylated interferon α and ribavirin therapy (PR therapy) has not been extensively studied in Korea. We aimed to clarify the prevalence of depression and its incidence during PR therapy in chronic hepatitis C (CHC) patients.
Methods: In this prospective, multicenter study, 114 CHC patients were screened for depression using two self-reported scales, the Beck Depression Inventory-I (BDI-I) and the Hospital Anxiety and Depression scale (HADS). The incidence of depression during PR therapy was evaluated in 62 patients who underwent PR therapy during the study period.
Results: The prevalence of baseline depression was 17.5% according to the BDI-I score ≥10 criterion and 4.4% according to the HADS-D score ≥8 criterion in the 114 CHC patients, and it was significantly associated with an unmarried state. During PR therapy, depression developed in 34.6% according to the BDI-I scale and 29.5% according to the HADS-D, which negatively affected sustained virologic response (SVR).
Conclusions: The prevalence of depression in Korean CHC patients appears to be low compared to that in Western patients; however, its incidence during PR therapy (approximately 30%) was similar to that of other populations, which led to a lower SVR rate. Active screening and multidisciplinary management of depression during PR therapy is warranted.
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KEYWORD
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Hepacivirus, Depression, Interferons, Beck Depression Inventory-I, Hospital Anxiety and Depression scale
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